DC Chemicals · Product datasheet

Briciclib(ON 013105,ON 014185) — Datasheet

CAT. NO. DC8179

Product page and current package options

ParameterValue
Chemical NameBriciclib
CAS No.865783-99-9
SynonymsBriciclib;2-Methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)vinyl]sulfonyl}methy l)phenyl dihydrogen phosphate;Phenol, 2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]-, 1-(dihydrogen phosphate);ON014185;ON-014185;WG93X96336;ON 014185;(E)-2-Methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl dihydrogen phosphate;Briciclib [USAN:INN];Phenol, 2-methoxy-5-((((1E)-2-(2,4,6-trimethoxyphenyl)ethenyl)sulfonyl)methyl)-, 1-(dihydrogen phosphate);Briciclib (USAN/INN);Briciclib; ON 014185
FormulaC19H23O10PS
M.Wt474.417
SMILESS(/C(/[H])=C(\[H])/C1C(=C([H])C(=C([H])C=1OC([H])([H])[H])OC([H])([H])[H])OC([H])([H])[H])(C([H])([H])C1C([H])=C([H])C(=C(C=1[H])OP(=O)(O[H])O[H])OC([H])([H])[H])(=O)=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Briciclib is a water soluble derivative of ON 013100, and has the potential in targeting eIF4E for solid cancers.

In Vitro

Briciclib has the potential in targeting eIF4E. Briciclib shows inhibitory activity against the proliferation of mantle cell leukemia (EKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines with GI50s of 9.8-12.2 nM, and with no toxicity on normal endothelial cells. Briciclib dose-dependently reduces the expression of cyclin D1 and c-Myc in breast and MCL cancer cell lines within 8 hours[1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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