DC Chemicals · Product datasheet

Xeglyze(Abametapir) — Datasheet

CAT. NO. DC8161

Product page and current package options

ParameterValue
Chemical NameAbametapir
CAS No.1762-34-1
Synonyms5,5'-Dimethyl-2,2'-bipyridine;5,5'-Dimethyl-2,2'-bipyridyl;5,5'-DIMETHYL-2,2'-DIPYRIDYL;5,5′-Dimethyl-2,2′-bipyridine;5-methyl-2-(5-methylpyridin-2-yl)pyridine;2,2'-BIPYRIDINE,5,5'-DIMETHYL;5,5'-dimethyl-2,2'-bipy;5,5'-dimethyl-2,2'-bispyridine;5,5'-dimethyl-bpy;6,6'-Bi-3-picoline;6,6'-Di-3-picoline;6,6'-Di-3-picolyl;Abametapir;Dimethylbipyridyl;2,2'-Bi(5-methylpyridine);5,5-DIMETHYL-2,2-DIPYRIDYL;5,5-Dimethyl-2,2-dipyridine;5,5’-dimethyl-2’-bipyridine;5,5-DIMETHYL-2,2-BIPYRIDINE;2,2'-BIPYRIDINE, 5,5'-DIMETHYL-;6UO390AMFB;5,5 -Dimethyl-2,2 -bipyridine;Xeglyze;Abametapir [USAN:INN];Xeglyze(Abametapir);5dm-Bpy;PubChem24353;Abametapir (USAN/INN)
FormulaC12H12N2
M.Wt184.2371
SMILESN1C([H])=C(C([H])([H])[H])C([H])=C([H])C=1C1C([H])=C([H])C(C([H])([H])[H])=C([H])N=1
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Abametapir is a metalloproteinase (MMP) inhibitor which is able to target metalloproteinases critical to egg hatching and louse development. Abametapir can inhibit hatching of both head and body louse[1][2].

In Vitro

Abametapir is capable of chelating heavy metal ions, including iron, copper, and zinc, and is therefore able to interact with a range of targets within the insect that require metal co-factors for function, including metalloproteinases[2].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

[1]. Vernon Morrison Bowles, et al. Effect of a New Head Lice Treatment, Abametapir Lotion, 0.74%, on Louse Eggs: A Randomized, Double-Blind Study. Glob Pediatr Health. 2019; 6: 2333794X19831295.

[2]. Vernon M. Bowles, et al. Ovicidal Efficacy of Abametapir Against Eggs of Human Head and Body Lice (Anoplura: Pediculidae). J Med Entomol. 2017 Jan; 54(1): 167-172.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Cart

Request quotation