DC Chemicals · Product datasheet

Raxatrigine hydrochloride — Datasheet

CAT. NO. DC8095

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ParameterValue
Chemical NameRaxatrigine HCl
CAS No.934240-31-0
Synonyms(5R)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-L-prolinamide hydrochloride;CNV1014802 hydrochloride;CNV-1014802 hydrochloride;GSK-1014802 hydrochloride;Raxatrigine hydrochloride;(2S,5R)-5-(4-((2-Fluorobenzyl)oxy)phenyl)pyrrolidine-2-carboxamide hydrochloride;7L3OLR4M8T;Raxatrigine HCl;CNV1014802 (hydrochloride);Raxatrigine hydrochloride [USAN];GSK2 HCl;CNV 1014802 hydrochloride;CNV1014802 HCl;GSK 1014802 HCl;Vixotrigine hydrochloride (USAN);cis-5-(4-((2-Fluorobenzyl)oxy)phenyl)pyrrolidine-2-carboxamid
FormulaC18H20ClFN2O2
M.Wt350.82
SMILESCl[H].FC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])OC1C([H])=C([H])C(=C([H])C=1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C(N([H])[H])=O)N1[H]
Purity>98%, ee>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

CNV1014802(GSK-1014802) Hcl is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor.IC50 value: Target: sodium channel blockerLike lamotrigine, both GSK2 and GSK3 were able to prevent the deficit in reversal learning produced by PCP, thus confirming their potential in the treatment of cognitive symptoms of schizophrenia. However, higher doses than those required for anticonvulsant efficacy of the drugs were needed for activity in the reversal-learning model, suggesting a lower therapeutic window relative to mechanism-dependent central side effects for this indication. CNV1014802 received orphan-drug designation from the US Food and Drug Administration in July 2013.

In Vitro

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In Vivo

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References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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