DC Chemicals · Product datasheet

Pyridostatin trifluoroacetate salt — Datasheet

CAT. NO. DC8091

Product page and current package options

ParameterValue
Chemical Name4-(2-Aminoethoxy)-N2,N6-bis[4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinedicarboxamide
CAS No.1085412-37-8
SynonymsRR82,RR-82
FormulaC31H32N8O5.XC2Hf3O2
M.Wt596.63(free base)
SMILESC(C(NC1C=C(OCCN)C2C(N=1)=CC=CC=2)=O)1=NC(C(NC2C=C(OCCN)C3C(N=2)=CC=CC=3)=O)=CC(OCCN)=C1.C(O)(=O)C(F)(F)F
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Pyridostatin is a G-quadruplexe stabilizer, with a Kd of 490 nM.

In Vitro

Pyridostatin is a G-quadruplexe stabilizer, with a Kd of 490 nM[1]. Pyridostatin (PDS) shows neurotoxic activity against primary cortical neurons at 0.01-5 μM, causes DNA double-strand breaks (DSBs) at 1 μM, downregulates BRCA1 in neurons at 1, 2 or 5 μM[2]. Pyridostatin interacts with G-quadruplex motifs in SRC and alters mRNA levels of damaged genes[3].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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