DC Chemicals · Product datasheet

kb NB 142-70 — Datasheet

CAT. NO. DC8084

Product page and current package options

ParameterValue
Chemical Name3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one
CAS No.1233533-04-4
Synonymskb-NB142-70;3,4-Dihydro-9-hydroxy-[1]benzothieno-[2,3-f]-1,4-thiazepin-5(2H)-one;3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one;kb NB 142-70;AG-L-65866;CHEBI:1169969;CHEMBL1672571;CS-1091;CTK8G0429;QCR-15;SureCN9920595;9-hydroxy-3,4-dihydro-2H-[1]benzothiolo[2,3-f][1,4]thiazepin-5-one;DHUAGGSHTKPOHU-UHFFFAOYSA-N;GTPL9369;AOB1401;SYN5189;HMS3740G15;BCP06729;BDBM50336960;3758AH;AB0094895;kb-
FormulaC11H9NO2S2
M.Wt251.3247
SMILESS1C([H])([H])C([H])([H])N([H])C(C2=C1C1C([H])=C(C([H])=C([H])C=1S2)O[H])=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

kb NB 142-70 is a selective protein kinase D (PKD) inhibitor. Demonstrates a 7-fold increase in inhibition potency as an analog of CID 755673. Reported to demonstrate prominent cytotoxic and anti-proliferative effects in vitro. Additionally noted to inhibit cell migration and invasion in a prostate cancer cell line. kb NB 142-70 is an inhibitor of PKC μ, PKC ν and PKD2. For the detailed information of kb NB 142-70, the solubility of kb NB 142-70 in water, the solubility of kb NB 142-70 in DMSO, the solubility of kb NB 142-70 in PBS buffer, the animal experiment (test) of kb NB 142-70, the cell expriment (test) of kb NB 142-70, the in vivo, in vitro and clinical trial test of kb NB 142-70, the EC50, IC50,and affinity,of kb NB 142-70, For the detailed information of kb NB 142-70, the solubility of kb NB 142-70 in water, the solubility of kb NB 142-70 in DMSO, the solubility of kb NB 142-70 in PBS buffer, the animal experiment (test) of kb NB 142-70, the cell expriment (test) of kb NB 142-70, the in vivo, in vitro and clinical trial test of kb NB 142-70, the EC50, IC50,and affinity,of kb NB 142-70, Please contact DC Chemicals.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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