DC Chemicals · Product datasheet

NG 52 (Compound 52 ) — Datasheet

CAT. NO. DC8076

Product page and current package options

ParameterValue
Chemical Name2-((6-((3-chlorophenyl)aMino)-9-isopropyl-9H-purin-2-yl)aMino)ethanol
CAS No.212779-48-1
SynonymsNG52, Compound52,NG-52,Compound-52
FormulaC16H19ClN6O
M.Wt346.81
SMILESCC(C)N1C=NC2=C1N=C(N=C2NC3=CC(=CC=C3)Cl)NCCO
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

NG 52 (Compound 52 ) is a potent, cell-permeable, reversible, selective, and ATP-compatible inhibitor of the cell cycle-regulating kinase, Cdc28p (IC50 = 7 μM), and the related Pho85p kinase (IC50 = 2 μM).Compound 52 inhibited growth in a drug-sensitized yeast strainwith a GI 50 of 30 uM. In contrast, the closely related compound 52Me proved to be a significantly weaker inhibitor of yeast growth (GI50=200 uM).

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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