DC Chemicals · Product datasheet

BX517 — Datasheet

CAT. NO. DC8062

Product page and current package options

ParameterValue
Chemical NameUrea, (2,3-dihydro-2-oxo-3-(1-(1H-pyrrol-2-yl)ethylidene)-1H-indol-5-yl)-
CAS No.850717-64-5
SynonymsBX517(PDK1 inhibitor2);BX517;SYV8VN8W5K;Urea, (2,3-dihydro-2-oxo-3-(1-(1H-pyrrol-2-yl)ethylidene)-1H-indol-5-yl)-;pdk-1 inhibitors;Urea, [2,3-dihydro-2-oxo-3-[1-(1H-pyrrol-2-yl)ethylidene]-1H-indol-5-yl]-;PDK1 inhibitor2;Indolinone based inhibitor, 4i;5-Ureido-3-(1-(pyrrol-2-yl)ethylidene)indolin-2-one;BDBM17004;BCP16225;s6504;Urea, N-(2,3-dihydro-2-oxo-3-((3Z)-1-(1H-pyrrol-2-yl)ethylidene)-1H-indol-5-yl
FormulaC15H14N4O2
M.Wt282.297
SMILESO=C1/C(=C(/C([H])([H])[H])\C2=C([H])C([H])=C([H])N2[H])/C2C([H])=C(C([H])=C([H])C=2N1[H])N([H])C(N([H])[H])=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

BX517 is a potent and selective inhibitor of PDK1 with IC50 of 6 nM.

In Vitro

BX-517 blocks activation of Akt in tumor cells, is potent with IC50 of 0.1-1.0 μM[1]. BX-517 blocks AKT2 activation in cells with submicromolar potency. BX-517 is 100-fold selective or better against a panel of seven additional Ser/Thr and Tyr kinases[2].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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