DC Chemicals · Product datasheet

Cyclo(-RGDfK) — Datasheet

CAT. NO. DC8055

Product page and current package options

ParameterValue
Chemical NameCyclo(-RGDfK)
CAS No.161552-03-0
Synonymscyclo (Arg-Ala-Asp-d-Phe-Lys);2-[(2S,5R,8S,11S)-8-(4-aminobutyl)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid;c(RGDfK);cyclo (Arg-Gly-Asp-d-Phe-Lys),c(RGDfK);CYCLO (RGDFK);Cyclo (-RGDfK);Cyclo(-Arg-Gly-Asp-D-Phe-Lys);Cyclic RGDfK peptide;cyclo (Arg-Gly-Asp-d-Phe-Lys);Cyclo(RGDfK) peptide;Cyclo(L-arginylglycyl-L-alpha-aspartyl-D-phenylalanyl-L-lysyl);CYCLO(-RGDFK);cyclo (Arg-Gly-Asp-Phe-Lys);Cyclo(-Arg-Gly-Asp-D-Phe-Lys) Trifluoroacetate salt;Cyclo(-RGDfK)
FormulaC27H41N9O7
M.Wt603.67054
SMILESO=C([C@H](CCCCN)NC([C@@H](CC1=CC=CC=C1)NC([C@H](CC(O)=O)NC(CN2)=O)=O)=O)N[C@@H](CCCNC(N)=N)C2=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM. Sequence: Cyclo(Arg-Gly-Asp-Phe-Lys).

In Vitro

Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with a IC50 of 0.94 nM[1]. [(66)Ga]DOTA-E-[c(RGDfK)]2 can be prepared with high radiochemical purity (>97%), specific activity (36-67GBq/μM), in vitro stability, and moderate protein binding. MicroPET imaging up to 24 post-injection showed contrasting tumors reflecting αvβ3-targeted tracer accumulation[2].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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