DC Chemicals · Product datasheet

AG-120 (Ivosidenib) — Datasheet

CAT. NO. DC8051

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ParameterValue
Chemical NameIvosidenib
CAS No.1448347-49-6
SynonymsIvosidenib;AG120;Tibsovo;Q2PCN8MAM6;(2S)-N-[(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl]-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide;(S)-N-((S)-1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide;RG120;ivosidenibum;(2S)-N-{(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-o
FormulaC28H22ClF3N6O3
M.Wt582.97
SMILESClC1=C([H])C([H])=C([H])C([H])=C1[C@@]([H])(C(N([H])C1([H])C([H])([H])C(C1([H])[H])(F)F)=O)N(C1C([H])=NC([H])=C(C=1[H])F)C([C@]1([H])C([H])([H])C([H])([H])C(N1C1C([H])=C(C#N)C([H])=C([H])N=1)=O)=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Ivosidenib (AG-120) is a mutant isocitrate dehydrogenase 1 (IDH1) inhibitor with an IC50 of 12 nM for mouse IDH1R132H.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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