DC Chemicals · Product datasheet

Bay 11-7085 — Datasheet

CAT. NO. DC8038

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ParameterValue
Chemical Name(E)-3-(4-Tert-butylphenylsulfonyl)acrylonitrile
CAS No.196309-76-9
Synonyms(E)-3-((4-(tert-Butyl)phenyl)sulfonyl)acrylonitrile;BAY 11-7085;(E)-3-(4-tert-butylphenyl)sulfonylprop-2-enenitrile;(E)-3-(4-tert-Butylphenylsulfonyl)acrylonitrile;2-Propenenitrile,3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-, (2E)-;BAY-11-7085;(E)-3-(4-t-Butylphenylsulfonyl)-2-propenenitrile;BAY 11-7083;BAY 117083;(E)-3-(T-BUTYLPHENYLSULFONYL)-2-PROPENENITRILE;(E)3-[(4-T-BUTYLPHENYL)SULFONYL]-2-PROPENENITRILE;(2E)-3-[[4-(1,1-DIMETHYLETHYL)PHENYL]SULFONYL]-2-PROPENENITRILE;BAY 117083 (2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile;(2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile BAY 11-7085;2-Propenenitrile, 3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-, (2E)-;Lopac0_000183;AOB6820;QC
FormulaC13H15NO2S
M.Wt249.3287
SMILESS(/C(/[H])=C(\[H])/C#N)(C1C([H])=C([H])C(=C([H])C=1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])(=O)=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

BAY 11-7085 is an inhibitor of NF-κB activation and phosphorylation of IκBα; it stabilizes IκBα with an IC50 of 10 μM.

In Vitro

BAY 11-7085 inhibits TNFa-induced surface expression of E-selectin, VCAM-1, and ICAM-1with IC50 values in the range of 5-10 μM. BAY 11-7085 stabilizes IκBα in a dose-dependent manner with an IC50 value of approximately 10 μM. There is a clear correlation between the concentration of drug that stabilized IκBα, the concentration that inhibits nuclear levels of NF-kB, and the concentration that inhibits adhesion molecule expression[1]. BAY 11-7085 has been shown to inhibit cell proliferation and induce apoptosis of a variety of cells. BAY 11-7085 (ECSCs) significantly inhibits the cell proliferation and DNA synthesis of ovarian endometriotic cyst stromal cells and induces apoptosis and the G0/G1 phase cell cycle arrest of these cells. BAY 11-7085 induces apoptosis of ECSCs by suppressing antiapoptotic proteins, and that caspase-3-, -8-, and -9-mediated cascades are involved in this mechanism[2].

In Vivo

BAY 11-7085 acts as an anti-inflammatory agent in both the rat carrageenan paw and the rat adjuvant arthritis model. It demonstrates a dose-dependent reduction in swelling in the rat carrageenan paw model[1].

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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