DC Chemicals · Product datasheet

CASIN — Datasheet

CAT. NO. DC8013

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ParameterValue
Chemical Name2-[(6-Phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino]ethanol
CAS No.425399-05-9
SynonymsCASIN;2-[(2,3,4,9-Tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]ethanol;Cdc42 Activity-Specific Inhibitor;2-[(6-phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino]ethanol;2-[(6-phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino]ethan-1-ol;CBMicro_003660;Pirl1-related Compound 2;Oprea1_416851;AOB2878;SMSF0012088;CASIN, >=98% (HPLC);BCP15785;CB05449;AK341038
FormulaC20H22N2O
M.Wt306.4015
SMILESO([H])C([H])([H])C([H])([H])N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C2C3C([H])=C(C4C([H])=C([H])C([H])=C([H])C=4[H])C([H])=C([H])C=3N([H])C1=2
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

CASIN is a selective GTPase Cdc42 inhibitor with IC50 of 2 uM.

In Vitro

Treatment with CASIN (5 uM) reduced the elevated level of active Cdc42 observed in aged primitive hematopoietic cells to the level observed in young cells.

In Vivo

Reverses the aging-related and polarity phenotype of aged HSCs to that of young HSCs.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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