DC Chemicals · Product datasheet

LDN-214117 — Datasheet

CAT. NO. DC7914

Product page and current package options

ParameterValue
Chemical Name1-(4-(6-Methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenyl)piperazine
CAS No.1627503-67-6
SynonymsLDN-214117;1-(4-(6-Methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenyl)piperazine;1-[4-[6-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]piperazine;1-{4-[6-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl}piperazine;compound 10 [PMID: 25101911];GTPL8481;AOB6448;BCP12392;3772AH;BDBM50056676;s7627;LDN214117;LDN 214117;SB19490;A16096;1-[4-[6-Methyl-
FormulaC25H29N3O3
M.Wt419.5161
SMILESO(C([H])([H])[H])C1C(=C(C([H])=C(C=1[H])C1=C(C([H])([H])[H])N=C([H])C(=C1[H])C1C([H])=C([H])C(=C([H])C=1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])OC([H])([H])[H])OC([H])([H])[H]
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

LDN-214117 is a potent and selective ALK2 inhibitor with IC50 of 22 nM; > 100 fold selectivity for ALK5; also inhibits BMP6(IC50=100 nM).IC50 value: 22 nM(ALK2) [1]Target: ALK2 inhibitorLDN-214117 is a highly BMP selective compound, significantly biased toward ALK2 and its cognate ligands including BMP6 and also demonstrates a high degree of kinome selectivity and lowcytotoxicity. LDN-214117 may be useful as highly selectiveprobes of BMP-mediated cellular physiology that may provide auseful complement to the dorsomorphin class of compounds. Furthermore, this class of BMP inhibitors offers a structurallydistinct template for the development of therapeutics for thetreatment of BMP signaling-mediated diseases such as FOP.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

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References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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