DC Chemicals · Product datasheet

CTX0294885 — Datasheet

CAT. NO. DC7904

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ParameterValue
Chemical Name2-((5-Chloro-2-((4-(piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide
CAS No.1439934-41-4
SynonymsCTX0294885;CTX-0294885;2-((5-chloro-2-((4-(piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide;2-[(5-chloro-2-{[4-(piperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]-N-methylbenzamide;AOB6978;BCP28558;2-(5-chloro-2-(4-(piperazin-1-yl)phenylaMino)pyriMidin-4-ylaMino)-N-MethylbenzaMide;BC600466;AK200604;B5843;A14121;5,6-Bis[(E)-benzylideneamino]-2-sulfan
FormulaC22H24ClN7O
M.Wt437.9253
SMILESClC1=C([H])N=C(N=C1N([H])C1=C([H])C([H])=C([H])C([H])=C1C(N([H])C([H])([H])[H])=O)N([H])C1C([H])=C([H])C(=C([H])C=1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

CTX-0294885 is a novel broad-spectrum kinase inhibitor. CTx-0294885 exhibits inhibitory activity against a broad range of kinases in vitro. Use of a quantitative proteomics approach confirmed the selectivity of CTx-0294885-bound beads for kinase enrichment. Large-scale CTx-0294885-based affinity purification followed by LC-MS/MS led to the identification of 235 protein kinases from MDA-MB-231 cells, including all members of the AKT family that had not been previously detected by other broad-spectrum kinase inhibitors. CTx-0294885 represents a powerful new reagent for analysis of kinome signaling networks that may facilitate development of targeted therapeutic strategies.For the detailed information of CTX0294885, the solubility of CTX0294885 in water, the solubility of CTX0294885 in DMSO, the solubility of CTX0294885 in PBS buffer, the animal experiment (test) of CTX0294885, the cell expriment (test) of CTX0294885, the in vivo, in vitro and clinical trial test of CTX0294885, the EC50, IC50,and affinity,of CTX0294885, Please contact DC Chemicals.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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