DC Chemicals · Product datasheet

7ACC2 — Datasheet

CAT. NO. DC7876

Product page and current package options

ParameterValue
Chemical Name7-(Benzyl(methyl)amino)-2-oxo-2H-chromene-3-carboxylic acid
CAS No.1472624-85-3
Synonyms7ACC-2;7ACC2;compound 19 [PMID: 24095010];7-ACC2;7-(Benzyl(methyl)amino)-2-oxo-2H-chromene-3-carboxylic acid;7-[benzyl(methyl)amino]-2-oxochromene-3-carboxylic acid;7ACC 2;GTPL8818;XTKDQPFUOFAMRL-UHFFFAOYSA-N;BCP11646;BDBM50442711;s6732;AK547419;Q27076338;2-Oxo-7-(methylbenzylamino)-2H-1-benzopyran-3-carboxylic acid;7-[methyl(phenylmethyl)amino]-2-oxo-2H-1-benzopyran-3-carboxylic acid
FormulaC18H15NO4
M.Wt309.316
SMILESO1C(C(C(=O)O[H])=C([H])C2C([H])=C([H])C(=C([H])C1=2)N(C([H])([H])[H])C([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H])=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for inhibition of [14C]-lactate influx; new antitumor treatment targeting lactate transport in cancer cells.IC50 value: 11 nM ([14C]-lactate influx) [1]Target: MCT inhibitor; lactate transport inhibitor7ACC2 did not influence the prothrombin time which, together with a good in vitro ADME profile, supports the potential of this new family of compounds to act as anticancer drugs through inhibition of lactate flux.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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