DC Chemicals · Product datasheet

MG149 — Datasheet

CAT. NO. DC7794

Product page and current package options

ParameterValue
Chemical Name2-[2-(4-Heptylphenyl)ethyl]-6-hydroxybenzoic acid
CAS No.1243583-85-8
SynonymsMG 149;2-(4-heptylphenethyl)-6-hydroxybenzoic acid;MG-149;MG149;2-[2-(4-heptylphenyl)ethyl]-6-hydroxybenzoic acid;Tip60 HAT inhibitor;MLS006010317;GTPL7488;BCP14627;BDBM50360449;s7476;SMR004701382;Y1879;A14267;Q27086037
FormulaC22O3H28
M.Wt340.4559
SMILESO([H])C1=C([H])C([H])=C([H])C(=C1C(=O)O[H])C([H])([H])C([H])([H])C1C([H])=C([H])C(=C([H])C=1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

MG149 is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM); little potent for PCAF and p300(IC50 >200 uM).IC50 value: 74/47 uM (Tip60/MOF) [1]Target: Tip60/MOFMG 149, at 200 μM, inhibited about 90% of Tip60 activity but had no inhibitory impact on p300 and PCAF. MG 149 was essentiallycompetitive with Ac-CoA and noncompetitive with the histone substrate. HAT inhibition studies with MG 149 demonstrated that both compounds inhibited the HAT activity of the nuclear extractsof different regions significantly (p < 0.05).

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Cart

Request quotation