DC Chemicals · Product datasheet

Emapunil(AC-5216) — Datasheet

CAT. NO. DC7731

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ParameterValue
Chemical NameEmapunil
CAS No.226954-04-7
Synonyms9H-Purine-9-acetamide,N-ethyl-7,8-dihydro-7-methyl-8-oxo-2-phenyl-N-(phenylmethyl)-;AC 5216;AC-5216;Emapunil;N-BENZYL-N-ETHYL-2-(7-METHYL-8-OXO-2-PHENYL-7H-PURIN-9(8H)-YL)ETHANAMIDE;N-benzyl-N-ethyl-2-(7-methyl-8-oxo-2-phenylpurin-9-yl)acetamide;AC1O5FL9;CHEBI:597751;CHEMBL513922;CTK4E9959;SureCN4757030;UNII-OG837L732J;XBD-173;N-Ethyl-7,8-dihydro-7-methyl-8-oxo-2-phenyl-N-(phenylmethyl)-9H-purine-9-acetamide;NVP-XBD173;9H-Purine-9-acetamide, N-ethyl-7,8-dihydro-7-methyl-8-oxo-2-phenyl-N-(phenylmethyl)-;émapunil;emapunilo;emapunilum;N-Benzyl-N-ethyl-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamid;N-Benzyl-N-ethyl-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide;N-Benzyl-N-éthyl-2-(7-méthyl-8-oxo-2-phényl-7,8-dihydro-9H-purin-9-yl)acétamide;XBD173;ac5216;AC-5216;XBD-173;emapunil(ac-5216);N-(benzyl)-N-ethyl-2-(8-keto-7-methyl-2-phenyl-purin-9-yl)acetamide;n-benzyl-n-ethyl-2-(7-methyl-8-oxo-2-phenyl-7h-purin-9(8h)-yl)acetamide;N-ethyl-2-(7-methyl-8-oxo-2-phenyl-9-purinyl)-N-(phenylmethyl)acetamide;N-ethyl-2-(7-methyl-8-oxo-2-phenylpurin-9-yl)-N-(phenylmethyl)acetamide;N-ethyl-2-(7-methyl-8-oxo-2-phenyl-purin-9-yl)-N-(phenylmethyl)acetamide;N-ethyl-2-(7-methyl-8-oxo-2-phenyl-purin-9-yl)-N-(phenylmethyl)ethanamide;SX-5216;UO7100000;XBD173 |
FormulaC23H23N5O2
M.Wt401.461024522781
SMILESO=C(CN1C2N=C(N=CC=2N(C)C1=O)C1C=CC=CC=1)N(CC)CC1C=CC=CC=1
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Emapunil(AC-5216;XBD-173) is a translocator protein[TSPO (18 kDa)] ligand.IC50 value:Target: TSPO ligandXBD173 enhanced gamma-aminobutyric acid-mediated neurotransmission and counteracted induced panic attacks in rodents in the absence of sedation and tolerance development. XBD173 also exerted antipanic activity in humans and, in contrast to benzodiazepines, did not cause sedation or withdrawal symptoms [1]. The selective TSPO ligand, XBD173 (AC-5216, Emapunil), exerts anxiolytic effects not only in animal models, but also in human volunteers [2].

In Vitro

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In Vivo

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References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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