DC Chemicals · Product datasheet

LCZ-696 — Datasheet

CAT. NO. DC7707

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ParameterValue
Chemical NameLCZ696
CAS No.936623-90-4
SynonymsSacubitril;3-(1-Biphenyl-4-ylMethyl-3-ethoxycarbonyl-1-butylcarbaMoyl)propionate-3'-Methyl-2'-(pentanoyl(2'-(tetrazol-5-ylate)biphenyl-4'-ylMethyl)aMino)butyrate;(S)-2-(N-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)hexanamido)-3-methylbutanoic acid compound with 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-me;Entresto(LCZ696);L-​Valine, N-​(1-​oxopentyl)​-​N-​[[2'-​(2H-​tetrazol-​5-​yl)​[1,​1'-​biphenyl]​-​4-​yl]​methyl]​-​, compd. with α-​ethyl (αR,​γS)​-​γ-​[(3-​carboxy-​1-​oxopropyl)​amino]​-​α-​methyl[1,​1'-​biphenyl]​;LCZ 696;LCZ-696;LCZ696 Entresto TM;Valsartan;BAL-4815;Isavuconazole;L-Valine, N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, compd. with α-ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl[1,1'-biphenyl]-4-pentanoate, sodium salt, hydrate (2:2:6:5);RO-0094815;trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-(S)-3-methyl-2-(pentanoyl{2”-(tetrazol-5-ylate)biphenyl-4-ylmethyl}amino)butyrate] hemipentahydrate;trisodium 3-((1S,3R)-1-(biphenyl-4-ylme;Sacubitril valsartan sodium hydrate;LCZ696
FormulaC96H120N12Na6O21
M.Wt1915.99
SMILESO=C(CCC([O-])=O)N([C@H](CC(C=C1)=CC=C1C2=CC=CC=C2)C[C@@H](C)C(OCC)=O)[H].[O-]C([C@@H](N(C(CCCC)=O)CC3=CC=C(C4=CC=CC=C4C5=NN=N[N-]5)C=C3)C(C)C)=O.[Na+].[Na+].[Na+].[2.5H2O]
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

LCZ696 is a dual angiotensin II receptor and neprilysin inhibitor.

In Vitro

LCZ696 is a single molecule that is comprised of molecular moieties of valsartan, an ARB, and AHU377, a neprilysin inhibitor (1:1 ratio)[1].

In Vivo

LCZ696 exerts a blood pressure lowering effect. Blood pressure reduction by LCZ696 is associated with a significant increase in urinary sodium excretion and sympathetic activity suppression. LCZ696 significantly ameliorates cardiac hypertrophy and inflammation, coronary arterial remodeling, and vascular endothelial dysfunction in high-salt loaded SHRcp compared with valsartan[1]. The neprilysin inhibitor component of LCZ696, LBQ657, inhibits hypertrophy but not fibrosis. The angiotensin receptor blocker component of LCZ696, valsartan inhibits both hypertrophy and fibrosis. Dual valsartan+LBQ augment the inhibitory effects of valsartan and the highest doses completely abrogate angiotensin II-mediated effects[2]. Pre-treatment with LCZ696 reduces the ischemic area. The decrease in cerebral blood flow in the peripheral region of the ischemic area is significantly attenuated by pre-treatment with LCZ696. LCZ696 pre-treatment significantly decreases the increase of superoxide anion production in the cortex on the ischemic side[3].

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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