EHT-1864 — Datasheet

Biological Activity

EHT 1864 selectively inhibits Rac-induced lamellipodia Formation, and specifically reverses cell trans Formation induced by constitutively activated mutants of Rac1 and Tiam1. EHT 1864 strongly impaires oncogenic Ras-induced cell proliferation in NIH 3T3 cells stably expressing H-Ras(61L) protein. EHT 1864 also reduces both extracellular and intracellular levels of Aβ peptides by inhibiting the γ-secretase-dependent cleavage of APP. In cultured hippocampal pyramidal neurons, EHT 1864, via inhibition of Rac1, rescues the phenotype induced by Rich2 knock-down. EHT 1864 (40 mg/kg i.p.) significantly reduces Abeta 40 and Abeta 42 levels in guinea pig brains. For the detailed information of EHT-1864, the solubility of EHT-1864 in water, the solubility of EHT-1864 in DMSO, the solubility of EHT-1864 in PBS buffer, the animal experiment (test) of EHT-1864, the cell expriment (test) of EHT-1864, the in vivo, in vitro and clinical trial test of EHT-1864, the EC50, IC50,and Affinity of EHT-1864, Please contact DC Chemicals.

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.