Biological Activity
Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma[1][2][3].
In Vitro
No in vitro data are provided in the current product source. Contact us for further information.
In Vivo
Assessment of Pharmacokinetics (PK) profile of Tazarotenic acid (Compound AGN 190299) after an intravenous of AGN 190168 in rats[1] . Male Female Male Dose (mg kg-1) 4.4 4.4 0.49 AUC (μg h mL-1) 9.31 (2.14) 9.78 (1.36) 0.594 (0.95) CL (mL min-1 kg-1) 7.96 (1.59) 7.62 (0.85) 14.0 (2.2) k (h-1) 0.562 (0.339) 0.820 (0.146) 0.741 (0.115) T1/2 (h) 1.64 (0.92) 0.86 (0.14) 0.95 (0.16) V0 (L kg-1) 0.43 (0.05) 0.49 (0.06) 1.31 (1.15) Vβ (L kg-1) - - 1.14 (0.09) Vmax (μg min-1) 9.08 (2.89) 6.09 (1.22) - Km (μg mL-1) 7.09 (1.35) 5.12 (1.19) -
References & source
Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.