DC Chemicals · Product datasheet

IOX1 — Datasheet

CAT. NO. DC7614

Product page and current package options

ParameterValue
Chemical Name8-Hydroxy-5-quinolinecarboxylic acid
CAS No.5852-78-8
Synonyms8-Hydroxyquinoline-5-carboxylic Acid;5-Carboxy-8-hydroxyquinoline;IOX 1;8-Hydroxy-5-quinolinecarboxylic acid;8-Hydroxy-chinolin-5-carbonsaeure;8-Hydroxy-chinolin-carbonsaeure-(5);8-hydroxy-quinoline-5-carboxylic acid;8XQ;AC1LA0UV;CHEMBL1230640;IOX-1;SureCN6068195;UNII-JM015YQC1C;IOX1;5-carboxy-8HQ;5-Quinolinecarboxylic acid, 8-hydroxy-;JM015YQC1C;4jht;4ie4;MLS002729056;GTPL8230;AOB6499;JGRPKOGHYBAVMW-UHFFFAOYSA-N;HMS3653E21;BCP16996;s7234;BDBM50396018;2184AH;IOX1, >=97% (HPLC);8-hydroxy-quinoline-5-c
FormulaC10H7NO3
M.Wt189.1675
SMILESO([H])C1C([H])=C([H])C(C(=O)O[H])=C2C([H])=C([H])C([H])=NC2=1
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

IOX1 is the most potent broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases; IC50 for KDM4A/KDM3A is 0.6/0.1 uM.IC50 value: 0.6/0.1 uM(KDM4A/KDM3A) [1]Target: JmjC KDMs inhibitorIOX1 is the most potent against a representative panel of 2OG oxygenases, including non-JmjC 2OG oxygenases, with an in vitro IC50 value in the micromolar range. However, its efficacy in cells is about a hundred-fold lower (HeLa cells, KDM4A, IC50 = 86uM), possibly due to low cell permeability resulting from itspolar C-5 carboxyl group.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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