DC Chemicals · Product datasheet

SGC-0946 — Datasheet

CAT. NO. DC7553

Product page and current package options

ParameterValue
Chemical Name1-[3-[[[(2R,3S,4R,5R)-5-(4-Amino-5--bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydro-xytetrahydrofuran-2-yl]methyl](isopropyl)amino]pro-pyl]-3-[4-(2,2-dimethylethyl)phenyl]urea
CAS No.1561178-17-3
SynonymsSGC0946,SGC 0946
FormulaC28H40BrN7O4
M.Wt618.57
SMILESCC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)C[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=C(C4=C3N=CN=C4N)Br)O)O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

SGC 0946 is over 100-fold selective For other histone methyltransferases/HMTs. SGC 0946 potently reduces H3K79 dimethylation with IC50 of 2.6 nM in A431 cells, and 8.8 nM in MCF10A cells, which potently and selectively kills cells containing an MLL translocation. SGC 0946 is much more potent than its close analog EPZ004777, and serves as an excellent chemical probe For investigating DOT1L and further development of DOT1L inhibitors For cancer therapy.For the detailed information of SGC-0946, the solubility of SGC-0946 in water, the solubility of SGC-0946 in DMSO, the solubility of SGC-0946 in PBS buffer, the animal experiment (test) of SGC-0946, the cell expriment (test) of SGC-0946, the in vivo, in vitro and clinical trial test of SGC-0946, the EC50, IC50,and Affinity of SGC-0946, Please contact DC Chemicals.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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