DC Chemicals · Product datasheet

Bromosporine — Datasheet

CAT. NO. DC7543

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ParameterValue
Chemical NameBromosporine
CAS No.1619994-69-2
SynonymsBromosporine;Carbamic acid, N-[3-methyl-6-[4-methyl-3-[(methylsulfonyl)amino]phenyl]-1,2,4-triazolo[4,3-b]pyridazin-8-yl]-, ethyl ester;Bromorsporine;Bioomosporine;GTPL8234;C17H20N6O4S;Bromosporine, >=98% (HPLC);AOB6807;HMS3653C21;2286AH;s7233;AK175193;A4186;SW219727-1;J3.656.836D;N-[(6-3-Methanesulfonamido-4-methylphenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyri
FormulaC17H20N6O4S
M.Wt404.4435
SMILESS(C([H])([H])[H])(N([H])C1=C(C([H])([H])[H])C([H])=C([H])C(=C1[H])C1C([H])=C(C2=NN=C(C([H])([H])[H])N2N=1)N([H])C(=O)OC([H])([H])C([H])([H])[H])(=O)=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Bromosporine is a broad spectrum inhibitor for bromodomains with IC50 of 0.41 μM, 0.29 μM, 0.122 μM and 0.017 μM for BRD2, BRD4, BRD9 and CECR2, respectively.IC50 value: 0.41/0.29/0.122/0.017 uM (BRD2/BRD4/BRD9/CECR2) [1]Target: BRD inhibitorIn cell-based assays, Bromosporine (1 μM) accelerates FRAP recovery of BRD4 and CREBBP, while shows no activities against TIF1α, BAZ2A, and SMARCA2 even at 10 μM. Bromosporine shows moderate cytotoxicity in HeLa cells at 18 μM. Bromosporine, as a chemical probe for bromodomain functional assays, will be very useful in elucidating further biological roles of reader domains.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

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References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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