DC Chemicals · Product datasheet

LH846 — Datasheet

CAT. NO. DC7454

Product page and current package options

ParameterValue
Chemical NameN-(5-Chloro-6-methyl-1,3-benzothiazol-2-yl)-2-phenylacetamide
CAS No.639052-78-1
SynonymsLH-846;Lh 846;N-(5-chloro-6-methyl-1,3-benzothiazol-2-yl)-2-phenylacetamide;N-(5-Chloro-6-methyl-2-benzothiazolyl)-benzeneacetamide;LH846;Benzeneacetamide, N-(5-chloro-6-methyl-2-benzothiazolyl)-;N-(5-chloro-6-methylbenzo[d]thiazol-2-yl)-2-phenylacetamide;N-(5-Chloro-6-methyl-benzothiazol-2-yl)-2-phenyl-acetamide;Oprea1_693221;N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide;AOB3510;BCP09669;STK241276;3782AH;BC600442;AK20
FormulaC16H13ClN2OS
M.Wt316.8052
SMILESClC1=C([H])C2=C(C([H])=C1C([H])([H])[H])SC(=N2)N([H])C(C([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H])=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

LH846 is a selective inhibitor of CKIδ, with an IC50 of 290 nM, and less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively.

In Vitro

LH846 is a potent inhibitor of CKIδ, with an IC50 of 290 nM, less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively, and has no effect on CK2. LH846 (3 or 10 μM) inhibits CKIδ-dependent phosphorylation of PER1 in HEK293T cells[1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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