DC Chemicals · Product datasheet

Ribociclib (LEE011) — Datasheet

CAT. NO. DC7453

Product page and current package options

ParameterValue
Chemical NameRibociclib Free Base
CAS No.1211441-98-3
SynonymsLEE011;7-?cyclopentyl-?N,?N-?dimethyl-?2-?[[5-?(1-?piperazinyl)?-?2-?pyridinyl]?amino]?-7H-?Pyrrolo[2,?3-?d];Ribociclib;LEE-011;7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;Ribociclib,LEE011;Ribociclib (LEE011);Kisqali;LEE 011;Ribociclib(LEE011);7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;TK8ERE8P56;AK174906;7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-Cyclopentyl-N,N-dimethyl-2-(5-(piperazin-1-yl)pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;7-cyclopentyl-2-(5-piperazin-1-yl-pyrid
FormulaC23H30N8O
M.Wt434.54
SMILESO=C(C1=C([H])C2=C([H])N=C(N([H])C3C([H])=C([H])C(=C([H])N=3)N3C([H])([H])C([H])([H])N([H])C([H])([H])C3([H])[H])N=C2N1C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])N(C([H])([H])[H])C([H])([H])[H]
Purity98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

LEE011, as dual CDK4/CDK6 inhibitor, significantly inhibits the growth of 12 of 17 neuroblastoma cell lines with mean IC50 of 307 nM. The growth inhibition of neuroblastoma cell lines is primarily cytostatic and is mediated by a G1 cell-cycle arrest and cellular senescence. LEE011 (200 mg/kg daily, p.o.) significantly causes tumor growth delay in mice harboring the BE2C or 1643 xenografts with no weight loss or other signs of toxicity. For the detailed information of LEE011, the solubility of LEE011 in water, the solubility of LEE011 in DMSO, the solubility of LEE011 in PBS buffer, the animal experiment (test) of LEE011, the cell expriment (test) of LEE011, the in vivo, in vitro and clinical trial test of LEE011, the EC50, IC50,and Affinity of LEE011, Please contact DC Chemicals.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Cart

Request quotation