DC Chemicals · Product datasheet

DY131 — Datasheet

CAT. NO. DC7405

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ParameterValue
Chemical NameBenzoic acid, p-hydroxy-, (p-(diethylamino)benzylidene)hydrazide
CAS No.95167-41-2
SynonymsBenzoic acid,4-hydroxy-, 2-[[4-(diethylamino)phenyl]methylene]hydrazide;DY131;DY131,N-(4-(Diethylaminobenzylidenyl)-N'-(4-hydroxybenzoyl)-hydrazine;Gsk 9089;DY-131;GSK-9089;4-Hydroxybenzoic acid 2-[[4-(diethylamino)phenyl]methylene]hydrazide;(E)-N'-(4-(diethylamino)benzylidene)-4-hydroxybenzohydrazide;C18H21N3O2;5VWV92039E;GSK9089;N-(4-(Diethylaminobenzylidenyl)-N'-(4-hydroxybenzoyl)-hydrazine;DY 131;(E)-N'-[4-(Diethylamino)benzylidene]-4-hydroxybenzohydrazide;N'-{[4-(diethylamino)phenyl]methylidene}-4-hydroxybenzohydrazide;BDBM22439;HMS3677A06;HMS3413A06;Benzoic acid, p-hydroxy-, (p-(diethylamino)benzylidene)hydrazide;ZIN
FormulaC18H21N3O2
M.Wt311.3782
SMILESO([H])C1C([H])=C([H])C(=C([H])C=1[H])C(N([H])/N=C(\[H])/C1C([H])=C([H])C(=C([H])C=1[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

DY131, a selective ERRγ agonist, could potentiate the ERRγ-induced growth inhibition in LNCaP- ERRγ and DU145- ERRγ cells in a dose-dependent manner compared with respective parental cells. DY131 inhibited the growth of the ERα-positive endometrial cancer cells but promoted that of the ERα-negative cancer cells. DY131 had no effect on the structurally related receptors ERRα or the estrogen receptors alpha and beta (ERalpha/beta). DY131 appears to inhibit Smo signaling through a common binding site shared by previously reported Smo agonists and antagonists. For the detailed information of DY131, the solubility of DY131 in water, the solubility of DY131 in DMSO, the solubility of DY131 in PBS buffer, the animal experiment (test) of DY131, the cell expriment (test) of DY131, the in vivo, in vitro and clinical trial test of DY131, the EC50, IC50,and Affinity of DY131, Please contact DC Chemicals.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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