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Dimethyloxaloylglycine(DMOG) — Datasheet

CAT. NO. DC7403

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ParameterValue
Chemical NameDimethyloxalylglycine
CAS No.89464-63-1
SynonymsGlycine,N-(2-methoxy-2-oxoacetyl)-, methyl ester;Dimethyloxaloylglycine;DMOG;Dimethyloxallyl Glycine;Dimethyloxaloylglycine (DMOG);Dimethyloxalylglycine;methyl 2-[(2-methoxy-2-oxoethyl)amino]-2-oxoacetate;N-(2-methoxy-2-oxoacetyl)Glycine methyl ester;N-(Methoxyoxoacetyl)-glycine methyl ester;N-[Methoxy(oxo)acetyl]glycine Methyl Ester;N-[(Methoxycarbonyl)methyl]oxamic acid methyl ester;methyl 2-((2-methoxy-2-oxoethyl)amino)-2-oxoacetate;BNJOZDZCRHCODO-UHFFFAOYSA-N;Glycine, N-(methoxyoxoacetyl)-, methyl ester;METHYL 2-(2-METHOXY-2-OXOETHYLAMINO)-2-OXOACETATE;methyl n-[methoxy(oxo)acetyl]glycinate;dimethyl oxalylglycine;methyl 2-(2-methoxy-2-oxoacetamido)acetate;Dimethy
FormulaC6H9NO5
M.Wt175.1394
SMILESO(C([H])([H])[H])C(C([H])([H])N([H])C(C(=O)OC([H])([H])[H])=O)=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

DMOG (Dimethyloxallyl Glycine) is a cell-permeable and competitive inhibitor of HIF-1α prolyl hydroxylase (HIF-PH).

In Vitro

DMOG efficiently suppresses hydroxyproline synthesis in intact cells, but shows only weakly active in the microsomal system[1]. DMOG reduces FGF-2-induced proliferation and cyclin A expression by inhibiting prolyl hydroxylase activity in HPASMC[3].

In Vivo

DMOG inhibits endogenous HIF inactivation, and induces angiogenesis in ischaemic skeletal muscles of mice[2]. Up-regulation of hypoxia-inducible factor-1α by DMOG enhances the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats[4].

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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