Biological Activity
CPAG-1 (PGRMC2 activator CPAG-1) is a small-molecule activator of PGRMC2. CPAG-1 treatment had no effect on weight or food intake but treated mice had reduced fasting glycemia and insulin levels. CPAG-1 decreased Rev-Erbα protein in BAT of CPAG-1-treated mice. CPAG-1 also significantly increased labile heme in the nucleus of brown adipocytes from CPAG-1-treated mice within 4 days of treatment.
In Vitro
No in vitro data are provided in the current product source. Contact us for further information.
In Vivo
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References & source
1. Andrea Galmozzi, et al. Nature. 2019 Dec;576(7785):138-142.
2. Christopher G Parker, et al. Cell. 2017 Jan 26;168(3):527-541.e29.
Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.