DC Chemicals · Product datasheet

Dapivirine — Datasheet

CAT. NO. DC7395

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ParameterValue
Chemical NameDapivirine
CAS No.244767-67-7
SynonymsBenzonitrile,4-[[4-[(2,4,6-trimethylphenyl)amino]-2-pyrimidinyl]amino]-;Dapivirine (TMC120);4-[[4-(2,4,6-trimethylanilino)pyrimidin-2-yl]amino]benzonitrile;4-[[4-[(2,4,6-Trimethylphenyl)amino]-2-pyrimidinyl]amino]benzonitrile;Dapivirine;TMC-120;4-({4-[(2,4,6-trimethylphenyl)amino]pyrimidin-2-yl}amino)benzenecarbonitrile;dapivirinum;R 147681;TMC120;UNII-TCN4MG2VXS;TMC 120;TMC 120R147681;R147681;Dapivirine(TMC120);TCN4MG2VXS;Benzonitrile, 4-[[4-[(2,4,6-trimethylphenyl)amino]-2-pyrimidinyl]amino]-;4-[4-(2,4,6-TRIMETHYL-PHENYLAMINO)-PYRIMIDIN-2-YLAMINO]-BENZONITRILE;AK326148;4-((4-(mesitylamino)pyrimidin-2-yl)amino)benzonitrile;4-({4-[(2,4,6-trimethylphenyl)amino]pyrimidin-2-yl}amino)benzonitr
FormulaC20H19N5
M.Wt329.3984
SMILESN([H])(C1C([H])=C([H])N=C(N([H])C2C([H])=C([H])C(C#N)=C([H])C=2[H])N=1)C1C(C([H])([H])[H])=C([H])C(C([H])([H])[H])=C([H])C=1C([H])([H])[H]
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

apivirine(TMC 120, TMC 120 R147681) is a NNRTI for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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