DC Chemicals · Product datasheet

CID-2011756 — Datasheet

CAT. NO. DC7253

Product page and current package options

ParameterValue
Chemical Name5-(3-Chlorophenyl)-N-[4-(morpholin-4-ylmethyl)phenyl]furan-2-carboxamide
CAS No.638156-11-3
SynonymsCID-2011756;5-(3-Chlorophenyl)-N-[4-morpholin-4-ymethyl)phenyl]furan-2-carboxamide;5-(3-Chlorophenyl)-N-(4-(morpholinomethyl)-phenyl)furan-2-carboxamide;5-(3-chlorophenyl)-N-[4-(morpholin-4-ylmethyl)phenyl]furan-2-carboxamide;CID 2011756;5-(3-chlorophenyl)-N-(4-(morpholinomethyl)phenyl)furan-2-carboxamide;MLS000557592;CID2011756;SMR000148508;5-(3-Chlorophenyl)-N-[4-(4-morpholinylmethyl)phenyl]-2-furancarboxamide;C22H21ClN2O3;5-(3-Chloro-phenyl)-furan-2-carboxylic acid (4-morpholin-4-ylmethyl-phenyl)-amide;Oprea1_481390;CH
FormulaC22H21ClN2O3
M.Wt396.8667
SMILESClC1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C(C(N([H])C2C([H])=C([H])C(=C([H])C=2[H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=O)O1
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

CID 2011756 is an ATP competitive PKD inhibitor, with an IC50 of 3.2 µM for PKD1 in cell free assay, and also shows cellular pan-PKD inhibitory activity against PKD2 and PKD3 (IC50, 0.6 and 0.7 µM, respectively). CID 2011756 also has antitumor activity.

In Vitro

CID 2011756 is an ATP-competitive PKD1 inhibitor, with an IC50 of 3.2 µM. CID 2011756 decreases the phosphorylation of endogenous PKD1 Ser916 in LNCaP cancer cells with an EC50 of 10±0.7 µM. CID 2011756 also has cellular pan-PKD inhibitory effects, with IC50s of 0.6±0.1 µM and 0.7±0.2 µM for PKD2 and PKD3, respectively[1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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