DC Chemicals · Product datasheet

NMS-873 — Datasheet

CAT. NO. DC7212

Product page and current package options

ParameterValue
Chemical NamePyridine,3-​[3-​(cyclopentylthio)​-​5-​[[[2-​methyl-​4'-​(methylsulfonyl)​[1,​1'-​biphenyl]​-​4-​yl]​oxy]​methyl]​-​4H-​1,​2,​4-​triazol-​4-​yl]​-
CAS No.1418013-75-8
SynonymsNMS873; NMS 873
FormulaC27H28N4O3S2
M.Wt520.67
SMILESCC1=C(C=CC(=C1)OCC2=NN=C(N2C3=CN=CC=C3)SC4CCCC4)C5=CC=C(C=C5)S(=O)(=O)C
Purity>99%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with IC50 value of 30 nM.

In Vitro

NMS-873 has antiproliferative effect on a panel of tumor cell lines with IC50 values in the range of 0.08 μM to 2 μM. For HCT116 and HeLa cells, the IC50 values are 0.4 μM and 0.7 μM, respectively. NMS-873 reduces VCP sensitivity to trypsin digestion, preventing degradation of the linker-D2 domain. NMS-873 induces clear, dose-dependent accumulation of poly-Ub proteins and stabilization of cyclin E and Mcl-1 at doses consistent with its antiproliferative IC50 value[1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Cart

Request quotation