Biological Activity
GSK2606414 is a cell-permeable and orally available PERK inhibitor with an IC50 of 0.4 nM.
In Vitro
GSK2606414 inhibits PERK activation in cells[1].
In Vivo
GSK2606414 (50 and 150 mg/kg, p.o.) inhibits the growth of a human tumor xenograft in mice[1].
References & source
Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.