DC Chemicals · Product datasheet

AdipoRon — Datasheet

CAT. NO. DC7049

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ParameterValue
Chemical NameAdipoRon
CAS No.924416-43-3
SynonymsAdipoRon;2-(4-Benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide;Acetamide, 2-​(4-​benzoylphenoxy)​-​N-​[1-​(phenylmethyl)​-​4-​piperidinyl]​-;SC-396658;2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]-acetamide;AdipoR agonist;AdipoRon hydrochloride;2-(4-Benzyoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamidehydrochloride;2-(4-Benzyoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide hydrochloride;ND7UVH6GKJ;2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide;C27H28N2O3;Acetamide,2-(4-benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]-;2-(4-Benzoylphenoxy)-N-(1-(phenylmethyl)-4-piperidinyl)acetamide;AMPD00101;HMS3653C18;BCP08895;ZLB41643;2197AH;BDBM50059083;s7365;STL507766;AM85966;MCULE;CCG-268984;CCG-268984;CCG-268984;CCG-268984;SY103513;SY103513;SY103513;SY103513;AS-35052;AS-35052;AS-35052;AS-35052;AC-35903;AC-35903;AC-35903;AC-35903;AN-465/43506510;AN-465/43506510;AN-465/43506510;AN-465/43506510;SCHEMBL17938602;SCHEMBL17938602;SCHEMBL17938602;SCHEMBL17938602;EX-A283;EX-A283;EX-A283;EX-A283;AKOS007999700;AKOS007999700;AKOS007999700;AKOS007999700;NCGC00370758-10;NCGC00370758-10;NCGC00370758-10;NCGC00370758-10;FT-0700407;FT-0700407;FT-0700407;FT-0700407;924416-43-3;924416-43-3;924416-43-3;924416-43-3;2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide;2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide;2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide;2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide;SB17384;SB17384;SB17384;MFCD08271060;SB17384;MFCD08271060;MFCD08271060;SW219831-1;MFCD08271060;SW219831-1;EN300-80366;SW219831-1;SW219831-1;EN300-80366;Z32352521;EN300-80366;EN300-80366;Z32352521;CHEMBL3393145;Z32352521;Z32352521;CHEMBL3393145;2-(4-benzoylphenoxy)-N-(1-benzyl-4-piperidinyl)acetamide;CHEMBL3393145;CHEMBL3393145;Acetamide, 2-(4-benzoylphenoxy)-N-(1-(phenylmethyl)-4-piperidinyl)-;2-(4-benzoylphenoxy)-N-(1-benzyl-4-piperidinyl)acetamide;2-(4-benzoylphenoxy)-N-(1-benzyl-4-piperidinyl)acetamide;2-(4-benzoylphenoxy)-N-(1-benzyl-4-piperidinyl)acetamide;UNII-ND7UVH6GKJ;Acetamide, 2-(4-benzoylphenoxy)-N-(1-(phenylmethyl)-4-piperidinyl)-;Acetamide, 2-(4-benzoylphenoxy)-N-(1-(phenylmethyl)-4-piperidinyl)-;Acetamide, 2-(4-benzoylphenoxy)-N-(1-(phenylmethyl)-4-piperidinyl)-;HY-15848;UNII-ND7UVH6GKJ;UNII-ND7UVH6GKJ;UNII-ND7UVH6GKJ;HY-15848;HY-15848;HY-15848
FormulaC27H28N2O3
M.Wt428.5228
SMILESO=C(C([H])([H])OC1C([H])=C([H])C(C(C2C([H])=C([H])C([H])=C([H])C=2[H])=O)=C([H])C=1[H])N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2C([H])=C([H])C([H])=C([H])C=2[H])C([H])([H])C1([H])[H]
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

AdipoRon is an orally active adiponectin receptor (AdipoR) agonist, binding to AdipoR1 and AdipoR2 with Kds of 1.8 and 3.1 μM, respectively.

In Vitro

AdipoRon is an orally active and specific AdipoR agonist, binds to AdipoR1 and AdipoR2, with Kds of 1.8 and 3.1 μM. AdipoRon (50 nM-50 μM) increases AMPK phosphorylation via AdipoR1[1]. AdipoRon (50 μM) dose-dependently attenuates the expression of TNF-α and TGF-β1 in the L02 cells. AdipoRon exhibits significant and dosage-dependent growth suppression on macrophages[2]. AdipoRon treatment significantly improves cardiac functional recovery after reperfusion, and inhibits post-MI apoptosis[3]. AdipoRon exerts vasodilation by mechanisms distinct to adiponectin and induces vasorelaxation without a marked decrease in VSMC [Ca2+]i[4].

In Vivo

AdipoRon is an orally active and specific AdipoR agonist, binds to AdipoR1 and AdipoR2, with Kds of 1.8 and 3.1 μM. AdipoRon (50 nM-50 μM) increases AMPK phosphorylation via AdipoR1[1]. AdipoRon (50 μM) dose-dependently attenuates the expression of TNF-α and TGF-β1 in the L02 cells. AdipoRon exhibits significant and dosage-dependent growth suppression on macrophages[2]. AdipoRon treatment significantly improves cardiac functional recovery after reperfusion, and inhibits post-MI apoptosis[3]. AdipoRon exerts vasodilation by mechanisms distinct to adiponectin and induces vasorelaxation without a marked decrease in VSMC [Ca2+]i[4].

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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