DC Chemicals · Product datasheet

AMG-47a — Datasheet

CAT. NO. DC7001

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ParameterValue
Chemical Name4-methyl-3-(2-((2-morpholinoethyl)amino)quinazolin-6-yl)-N-(3-(trifluoromethyl)phenyl)benzamide
CAS No.882663-88-9
SynonymsAMG-47a;4-Methyl-3-(2-((2-morpholinoethyl)amino)quinazolin-6-yl)-N-(3-(trifluoromethyl)phenyl)benzamide;4-methyl-3-[2-(2-morpholin-4-ylethylamino)quinazolin-6-yl]-N-[3-(trifluoromethyl)phenyl]benzamide;4-methyl-3-(2-(2-morpholinoethylamino)quinazolin-6-yl)-N-(3-(trifluoromethyl)phenyl)benzamide;C29H28F3N5O2;PubChem22409;AMG47a;AOB6159;SYN1007;BCPP000408;HMS3244I05;HMS3244I06;HMS3244J05;BCP01962;BDBM50194668;s2213
FormulaC29H28F3N5O2
M.Wt535.5601
SMILESFC(C1C([H])=C([H])C([H])=C(C=1[H])N([H])C(C1C([H])=C([H])C(C([H])([H])[H])=C(C=1[H])C1C([H])=C([H])C2C(=C([H])N=C(N=2)N([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C=1[H])=O)(F)F
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

AMG-47a is a potent inhibitor of Lck and T cell proliferation; exhibits anti-inflammatory activity (ED50 = 11 mg/kg) in the anti-CD3 induced production of IL-2 in mice.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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