DC Chemicals · Product datasheet

RMC-9805（Zoldonrasib） — Datasheet

CAT. NO. DC60568

Product page and current package options

ParameterValue
Chemical NameKRAS G12D inhibitor 18
CAS No.2922732-54-3
SynonymsSCHEMBL26348957;HY-156819;2922732-54-3;RMI-5921;EX-A8179;KRAS G12D inhibitor 18;CS-0897768
FormulaC63H88F3N11O7
M.Wt1168.43754577637
SMILESFC(CN1C(C2=C([C@H](C)OC)N=CC(=C2)N2CCN(CC2)C2CC2)=C2CC(C)(C)COC([C@@H]3CCCN(C([C@H](C[C@H]4CN(C5=CC=C1C2=C5)CCO4)NC([C@H](C1CCCC1)N1CC[C@@]2(C1)CCN(C2)C([C@H]1[C@@H](C2CC2)N1C)=O)=O)=O)N3)=O)(F)F
Purity98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

RMC-9805 is a first-in-class, mutant-selective, covalent and orally bioavailable KRAS-G12D(ON) inhibitor. RMC-9805 exhibits direct anti-tumor effects and indirectly transformed the TME through inhibition of cancer cell-intrinsic KRAS-G12D oncogenic signaling.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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