DC Chemicals · Product datasheet

DNL343 — Datasheet

CAT. NO. DC60528

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ParameterValue
Chemical NameDNL343; SCHEMBL20734077; SCHEMBL23358949; SCHEMBL24226229; DNL-343; DNL 343
CAS No.2278265-85-1
Synonyms2-(4-chlorophenoxy)-N-(3-(5-((1s,3s)-3-(trifluoromethoxy)cyclobutyl)-1,3,4-oxadiazol-2-yl)bicyclo[1.1.1]pentan-1-yl)acetamide
FormulaC20H19ClF3N3O4
M.Wt457.830
SMILESFC(F)(F)O[C@@H]1C[C@H](C2=NN=C(C34CC(C4)(NC(COC5=CC=C(Cl)C=C5)=O)C3)O2)C1
Purity98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

DNL343 is a potent, selective, and brain-penetrant eukaryotic translation initiation factor 2B (eIF2B) activator with ATF4 IC50 of 9.8 nM.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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