DC Chemicals · Product datasheet

LUNA18 — Datasheet

CAT. NO. DC60527

Product page and current package options

ParameterValue
Chemical NameLUNA18
CAS No.2676177-63-0
Synonyms2-((5S,8S,11S,14S,17S,22aS,28S,34S,36aS)-8-((S)-sec-Butyl)-17-cyclopentyl-28-(3,5-difluoro-4-(trifluoromethyl)phenethyl)-35-ethyl-11-isobutyl-5,6,12,15,18,32-hexamethyl-34-(4-methylbenzyl)-4,7,10,13,16,19,22,27,30,33,36-undecaoxotetratriacontahydro-2H-spiro[azeto[1,2-a]pyrrolo[1,2-m][1,4,7,10,13,16,19,22,25,28,31]undecaazacyclotritriacontine-20,1'-cyclopentan]-14-yl)-N,N-dimethylacetamide
FormulaC73H105F5N12O12
M.Wt1,437.710
SMILESO=C(N(C)C)C[C@@H](C(N(C)[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(N(C)[C@H]1C)=O)=O)=O)N(C)C([C@H](C2CCCC2)N(C)C(C3(CCCC3)NC([C@@](CCC4)([H])N4C([C@H](CCC5=CC(F)=C(C(F)(F)F)C(F)=C5)NC(CN(C)C([C@H](CC6=CC=C(C)C=C6)N(CC)C([C@@](CC7)([H])N7C1=O)=O)=O)=O)=O)=O)=O)=O
Purity98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

LUNA18 is an 11-mer cyclic peptide inhibitor for the intracellular tough target RAS with Kd (KRAS/G12D) of 0.043 nM and cellular IC50 of 1.4 nM (AsPC-1). LUNA18 orally and dose-dependently exhibits potent anti-cancer activities in a mouse xenograft model. LUNA18 shows 21–47% oral bioavailability in animals such as mouse, rat, monkey, and dog and notably does not require special formulations.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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