Biological Activity
BRD7586 is a cell-permeable small molecule inhibitor of SpCas9 with EC50 of 6.2 µM and 5.7 µM in the eGFP-disruption and HiBiT-knock-in assays, respectively. BRD7586 specifically engages SpCas9 but not Cas12a in cells and enhances SpCas9 specificity at multiple loci.
In Vitro
No in vitro data are provided in the current product source. Contact us for further information.
In Vivo
No in vivo data are provided in the current product source. Contact us for further information.
References & source
A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules-Donghyun Lim, Qingxuan Zhou, etl. Nature Cell Biology volume 24, pages1766–1775 (2022)Cite this article
Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.