TRPM4-IN-2 Datasheet | DC60304

TRPM4-IN-2 — Datasheet

CAT. NO. DC60304

Parameter	Value
Chemical Name	TRPM4-IN-2
CAS No.	667411-04-3
Synonyms	Benzoic acid, 4-chloro-2-[[2-(1-naphthalenyloxy)acetyl]amino]-;TRPM4-IN-2
Formula	C19H14ClNO4
M.Wt	355.77
SMILES	C(O)(=O)C1=CC=C(Cl)C=C1NC(COC1=C2C(C=CC=C2)=CC=C1)=O
Purity	>98%
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

TRPM4-IN-2 (NBA) is a potent transient receptor potential melastatin 4 (TRPM4) inhibitor with an IC50 value of 0.16 μM. TRPM4-IN-2 can be used for researching prostate cancer and colorectal cancer[1][2].

In Vitro

TRPM4-IN-2 (NBA) (50 μM; 0-500 s) blocks the endogenous TRPM4 currents in DU145[1]. Cell Proliferation Assay[1] Cell Line: DU145 Concentration: 50 μM Incubation Time: 0-500 s Result: Blocked 88 ± 9% of the endogenous TRPM4 currents at 50 μM.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

Target

TRPM4:0.16 μM (IC50)

References & source

[1]. Borgström A, et al. Small Molecular Inhibitors Block TRPM4 Currents in Prostate Cancer Cells, with Limited Impact on Cancer Hallmark Functions. J Mol Biol. 2021 Aug 20;433(17):166665.

[2]. Stokłosa P, et al. Investigation of Novel Small Molecular TRPM4 Inhibitors in Colorectal Cancer Cells. Cancers (Basel). 2021 Oct 28;13(21):5400.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.