DC Chemicals · Product datasheet

SHIN2 — Datasheet

CAT. NO. DC60152

Product page and current package options

ParameterValue
Chemical NameSHIN 2, SHIN-2
CAS No.2204289-53-0
Synonyms6-Amino-4-(3-(hydroxymethyl)-5-(5-hydroxypent-1-yn-1-yl)phenyl)-4-isopropyl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
FormulaC23H26N4O3
M.Wt406.49
SMILESN#CC(C1(C2=CC(C#CCCCO)=CC(CO)=C2)C(C)C)=C(N)OC3=C1C(C)=NN3
Purity>98%
Storage0°C (short term), -20°C (long term), desiccated

Biological Activity

SHIN-2 is a novel SHMT inhibitor, increasing survival in NOTCH1-driven mouse primary T-ALL in vivo

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

1) Juan C. García-Cañaveras et. eal., SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia, Leukemia volume 35, pages377–388 (2021)

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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