DC Chemicals · Product datasheet

MYF-01-37 — Datasheet

CAT. NO. DC60085

Product page and current package options

ParameterValue
Chemical NameSchembl21958179
CAS No.2416417-65-5
Synonymss8950;1-(3-Methyl-3-((3-(trifluoromethyl)phenyl)amino)pyrrolidin-1-yl)prop-2-en-1-one;Schembl21958179
FormulaC15H17F3N2O
M.Wt298.3035
SMILESFC(C1C([H])=C([H])C([H])=C(C=1[H])N([H])C1(C([H])([H])[H])C([H])([H])N(C(C([H])=C([H])[H])=O)C([H])([H])C1([H])[H])(F)F
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

MYF-01-37 is a covalent TEAD inhibitor targeting Cys380. MYF-01-37 has a reversible inhibition on YAP/TEAD interaction[1].

In Vitro

MYF-01-37 (10 μM; 24h) results in inhibition of direct YAP/TEAD interaction in HEK 293T cells, and in the reduction in canonical YAP target gene CTGF expression in PC-9 cells[1]. MYF-01-37 (0.1, 1, 10, 100 μM) has minimal impact on cell viability of several EGFR-mutant NCSLC cell lines[1]. MYF-01-37 (10 μM; 10 days) combinated with OT (combination of osimertinib and trametinib) leads to a dramatic decrease in dormant cells compared to OT alone[1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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