DC Chemicals · Product datasheet

XL177A — Datasheet

CAT. NO. DC60006

Product page and current package options

ParameterValue
Chemical NameN'-hydroxy-4-methylpentanimidamide
CAS No.2417089-74-6
SynonymsN-hydroxy-4-methylpentanamidine;Bio-Farma Bf034349;Bio-Farma Bf034349(WX690181);N'-hydroxy-4-methylpentanimidamide;N-Hydroxy-4-methylpentanimidamide;(E)-N'-hydroxy-4-methylpentimidamide;Pentanimidamide, N-hydroxy-4-methyl-;pentanimidamide,n-hydroxy-4-methyl-;W10718
FormulaC6H14N2O
M.Wt130.1882
SMILESO([H])/N=C(/C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])\N([H])[H]
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

XL177A is a potent USP7 inhibitor. XL177A irreversibly inhibits USP7 with sub-nM potency and selectivity across the human proteome. Evaluation of the cellular effects of XL177A reveals that selective USP7 inhibition suppresses cancer cell growth predominantly through a p53-dependent mechanism: XL177A specifically upregulates p53 transcriptional targets transcriptome-wide, hotspot mutations in TP53 but not any other genes predict response to XL177A across a panel of ~500 cancer cell lines, and TP53 knockout rescues XL177A-mediated growth suppression of TP53 wild-type (WT) cells.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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