DC Chemicals · Product datasheet

SN-38(NK-012) — Datasheet

CAT. NO. DC5905

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ParameterValue
Chemical NameSN-38
CAS No.86639-52-3
Synonyms7-Ethyl-10-hydroxycamptothecin;CAMPTOTHECIN, 10-HYDROXY-;CAMPTOTHECIN, 10-HYDROXY-, CAMPTOTHECA ACUMINATA;HCPT;HYDROXYCAMPTOTHECIN;HYDROXYCAMPTOTHECIN, 10-;SN38;1H-Pyrano3,4:6,7indolizino1,2-bquinoline-3,14(4H,12H)-dione, 4-ethyl-4,10-dihydroxy-;7-Ethyl-10-hydroxy-camptothecine;4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;7-Ethyl-10-Hydroxy-Camptothecin;7-Ethyl-10-hydroxycamptothecin(SN38);7-Ethyl-10-Hydroxycamptothecin(SN-38);7-Ethyl-10-hydroxycamptothecine;SN-38;(S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;1-Ethoxy-2-propanol;Irinotecan Related CoMpound B;NK012;NK-012;(4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione;SN 38 lactone;SN 38;10-Hydroxy-7-ethylcamptothecin;NK 012;NSC673596;0H43101T0J;7–Ethyl–10–hydroxycamptothecin;UQ0491000;(+)-7-ETHYL-10-HYDROXYCAMPTOTHECIN;(4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione;10.1158/0008-5472.CAN-03-3344;1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4,7-diethyl-4,10-dihydroxy-;7???ethyl???10???hydroxycamptothecin;7-Ethyl-10- hydroxycamptothecin;7-Ethyl-10-hydroxy camptothecin;7-ethyl-10-hydroxy camptothecine;7-Ethyl-10-hydroxy-20(S)-camptothecin;7-Ethyl-10-hydroxy-20-(S)-camptothecine;7-Ethyl-10-hydroxycamptothecin |;7-Ethyl-10-hydroxycamptothecin|SN 38;7-ETHYL-10-HYDROXY-CAPTOTHECIN;BR-36613;Captothecin, 7-ethyl-10-hydroxy-;CHEBI:8988;EHC;https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:8988;LE-SN38;SN 38; SN38;NK-012;NK012;NK 012;SN-38-d3;UNII:0H43101T0J;UNII-0H43101T0J;(4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione (ACI);1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-, (S)- (ZCI);(19S)-10,19-Diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0[2,11].0[4,9].0[15,20]]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione;(S)-SN 38;SN 38 (pharmaceutical);7-Ethyl-10-hydroxycamptothecin (SN-38)
FormulaC22H20N2O5
M.Wt392.404605865479
SMILESC(C1C2C=C(C=CC=2N=C2C3=CC4[C@@](C(OCC=4C(=O)N3CC=12)=O)(O)CC)O)C
Purity>98%
Storage4°C for 1 year, -20°C for more than 2 years

Biological Activity

SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively.

In Vitro

The IC50 values for LoVo, HCT116, and HT29 cell lines is 20 nM, 50 nM, 130 nM, respectively. In all three SN-38 resistant cell lines Top1 activity is maintained in the presence of high concentrations of SN-38[2].

In Vivo

SN-38, the active and toxic metabolite of the anticancer prodrug Irinotecan. At 30 minutes after administration, Irinotecan plasma concentrations in Slco1a/1b(−/−) mice are 1.9-fold higher than in the wild-type mice (1.89 vs. 1.01 μM, respectively), whereas SN-38 plasma concentrations of Slco1a/1b(−/−) mice are 8-fold higher compare with wild-type mice (0.4 μg/mL vs. 0.05 μg/mL, respectively). Overall plasma exposure [AUC(5-240)] of Irinotecan is 1.7-fold higher in Oatp1a/1b knockout mice versus wild-type mice (209.8±6.7 vs. 120.9±4.4 μM/min; P<0.01), and 2.9-fold higher for SN-38 (50±2.9 vs. 12±2 μM/min; P<0.001)[3].

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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