PLX5622 hemifumarate Datasheet | DC59018

PLX5622 hemifumarate — Datasheet

CAT. NO. DC59018

Parameter	Value
Chemical Name	PLX5622 hemifumarate
Formula	C46H42F4N10O6
M.Wt	906.90
SMILES	COc1ncc(F)cc1CNc1ccc(Cc2c[nH]c3ncc(C)cc23)c(F)n1.COc1ncc(F)cc1CNc1ccc(Cc2c[nH]c3ncc(C)cc23)c(F)n1.O=C(O)/C=C/C(=O)O
Purity	>98%
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Structure and molecular-weight basis	Full hemifumarate formula unit: two PLX5622 molecules plus one fumaric acid molecule. Reference 453.45 is per PLX5622 equivalent; full formula-unit mass is 906.90.

Chemical identity references

Biological Activity

PLX5622 hemifumarate is a highly selective brain penetrant and orally active CSF1R inhibitor (IC50=0.016 µM; Ki=5.9 nM). PLX5622 hemifumarate allows for extended and specific microglial elimination, preceding and during pathology development. PLX5622 hemifumarate demonstrates desirable PK properties in varies animals.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.