DC Chemicals · Product datasheet

GSK3685032 — Datasheet

CAT. NO. DC58007

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ParameterValue
Chemical NameGSK3685032 HCl
CAS No.2170137-61-6
Synonymsα-[[6-(4-Amino-1-piperidinyl)-3,5-dicyano-4-ethyl-2-pyridinyl]thio]benzeneacetamide;GSK3685032;GSK3685032 HCl;GTPL11750;BDBM491199;NSC837081;US10975056, Example 143
FormulaC22H24N6OS
M.Wt420.5306
SMILESS(C([H])(C(N([H])[H])=O)C1C([H])=C([H])C([H])=C([H])C=1[H])C1=C(C#N)C(C([H])([H])C([H])([H])[H])=C(C#N)C(=N1)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])N([H])[H]
Purity>98%
Storage-20-4°C

Biological Activity

GSK-3685032(GSK 3685032) is a first-in-class, potent, non-nucleoside, reversible, selective inhibitor of DNMT1 with IC50 of 0.036 μM. GSK3685032 induces robust loss of DNA methylation, transcriptional activation and cancer cell growth inhibition in vitro.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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