DC Chemicals · Product datasheet

NSC-664704(Kenpaullone) — Datasheet

CAT. NO. DC5093

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ParameterValue
Chemical NameKenpaullone
CAS No.142273-20-9
SynonymsIndolo[3,2-d][1]benzazepin-6(5H)-one,9-bromo-7,12-dihydro-;Kenpaullone;8-Bromo-7,12-Dihydro-Indolo[3,2-D][1]-Benzazepin-6(5H)-One;9-bromo-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one;9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one;9-Bromopaullone;NSC-664704;9-Bromo-7,12-dihydro-indolo­[3,2-d]­[1]benzazepin-6(5H)-one;NSC 664704;9-Bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one;NSC664704;MLS002702152;QQUXFYAWXPMDOE-UHFFFAOYSA-N
FormulaC16H11BrN2O
M.Wt327.1753
SMILESBrC1C([H])=C([H])C2=C(C=1[H])C1C([H])([H])C(N([H])C3=C([H])C([H])=C([H])C([H])=C3C=1N2[H])=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Kenpaullone is an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) as well as glycogen synthase kinase 3β (GSK3β).It inhibits GSK3β with an IC50 value of 0.023 µM (0.23 µM) and Cdk1/cyclin B, Cdk2/cyclin A, Cdk5/p25, and lymphocyte kinase with IC50 values of 0.4, 0.68, 0.85, and 0.47 µM, respectively.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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