DC Chemicals · Product datasheet

GSK-114 — Datasheet

CAT. NO. DC50026

Product page and current package options

ParameterValue
Chemical NameGSK-114
CAS No.1301761-96-5
Synonyms3-((6,7-dimethoxyquinazolin-4-yl)amino)-4-(dimethylamino)-N-methylbenzenesulfonamide;3-[(6,7-dimethoxyquinazolin-4-yl)amino]-4-(dimethylamino)-N-methylbenzenesulfonamide;GSK 114;BDBM50178310;3-{[6,7-bis(methyloxy)-4-quinazolinyl]amino}-4-(dimethylamino)-N-methylbenzenesulfonamide;GSK-114;1301761-96-5;AKOS040745041;SCHEMBL12003690;GSK-114?;EX-A4550;YUSROMRPOFFTMX-UHFFFAOYSA-N;CS-0066770;MS-27285;DA-53722;G66230;HY-117658;CHEMBL3815093
FormulaC19H23N5O4S
M.Wt417.48202252388
SMILESS(C1C=CC(=C(C=1)NC1C2C=C(C(=CC=2N=CN=1)OC)OC)N(C)C)(NC)(=O)=O
Purity98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

GSK-114 is a potent and selective selective TNNI3K inhibitor (TNNI3 IC50 = 25nM; B-RafV600E IC50 = 1000 nM). GSK-114 displays significant bias (40-fold) for TNNI3K over B-Raf, exceptional broad spectrum kinase selectivity, and adequate oral exposure to en

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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