DC Chemicals · Product datasheet

Bezuclastinib — Datasheet

CAT. NO. DC48359

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ParameterValue
Chemical Name4,5-dimethyl-N-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazole-3-carboxamide
CAS No.1616385-51-3
Synonyms4,5-dimethyl-N-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazole-3-carboxamide;Bezuclastinib;3,4-Dimethyl-N-(2-phenyl-1H-pyrrolo(2,3-b)pyridin-5-yl)-1H-pyrazole-5-carboxamide;3,4-dimethyl-N-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazole-5-carboxamide;2ROQ545LAG;CGT9486;PLX 9486 [WHO-DD];BDBM392363;3,4-dimethyl-N-(2-phenyl-1H- pyrrolo[2,3-b]pyridin-5-yl)-1H- pyrazole-5-carboxamide
FormulaC19H17N5O
M.Wt331.3712
SMILESO=C(C1C(C([H])([H])[H])=C(C([H])([H])[H])N([H])N=1)N([H])C1=C([H])N=C2C(=C1[H])C([H])=C(C1C([H])=C([H])C([H])=C([H])C=1[H])N2[H]
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Bezuclastinib (PLX 9486; CGT9486) is a potent inhibitor of c-kit and c-kit D816V (0.0001<IC50<1 μM; extracted from patent WO2014100620 A2, compound P-2007). Bezuclastinib is a tyrosine kinase inhibitor.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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