Biological Activity
SBP-3264 (SBP3264) is a sepecific inhibitor of Hippo signaling pathway kinases STK3 and STK4 with low nanomolar potency. SBP-3264 specifically inhibited the Hippo signaling pathway in cultured mammalian cells and possessed favorable pharmacokinetic and pharmacodynamic properties in mice. SBP-3264 suppress the proliferation of AML cells in vitro. SBP-3264 is a valuable chemical probe for understanding the roles of STK3 and STK4 in AML.
In Vitro
No in vitro data are provided in the current product source. Contact us for further information.
In Vivo
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References & source
1. Nicole Bata, et al. J Med Chem. 2022 Jan 27;65(2):1352-1369.
Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.