DC Chemicals · Product datasheet

PF-07220060 — Datasheet

CAT. NO. DC46946

Product page and current package options

ParameterValue
Chemical NameCDK4/6-IN-6
CAS No.2380321-51-5
SynonymsPF-07220060;1,5-anhydro-3-((5-chloro-4-[4-fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1 H-benzimidazol-6- yl]pyrimidin-2-yl)amino)-2,3-dideoxy-D-threo-pentitol;CDK4/6-IN-6CDK4/CDK4/6-IN-66-IN-6
FormulaC22H27ClFN5O3
M.Wt463.93
SMILESC(N1C(=NC2=C(C=C(C3C(=CN=C(N[C@@H]4CCOC[C@H]4O)N=3)Cl)C=C12)F)C(O)(C)C)(C)C
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

PF-07220060 is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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