BRM/BRG1 ATP Inhibitor-1 Datasheet | DC46193

BRM/BRG1 ATP Inhibitor-1 — Datasheet

CAT. NO. DC46193

Parameter	Value
Chemical Name	BRM/BRG1 ATP Inhibitor-1
CAS No.	2270879-17-7
Synonyms	BRM/BRG1 ATP Inhibitor-1;1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea;TQR0285;Dual BRM and BRG1 inhibitor 14;BDBM50469330
Formula	C11H9F3N4O2S
M.Wt	318.274970769882
SMILES	S1C(=CC(C(F)F)=N1)NC(NC1C=C(N=CC=1CO)F)=O
Purity	>98%
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

BRM/BRG1 ATP Inhibitor-1 is an allosteric dual brahma homolog (BRM)/SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 (SMARCA2) and brahma related gene 1 (BRG1)/SMARCA4 ATPase activity inhibitor, both IC50s are below 0.005 µM[1].

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

Target

IC50: ﹤0.005 µM (BRM, BRG1)[1]

References & source

[1]. Papillon JPN, et al. Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. J Med Chem. 2018 Nov 21;61(22):10155-10172

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.